|(2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-3-((2R,5S)-5-(2-羟基丙烷-2-基)-2-甲基四氢呋喃-2-基)-2a,5a,8,8-四甲基十六氢环戊并[a]环丙烷并[e]菲-4,7,9-三醇|CsnPharm

CAS No.: 78574-94-4

环黄芪醇 Catalog No. CSN23528

Synonyms: Astramembrangenin;Cyclosieversigenin;环黄芪醇

Cycloastragenol exhibits telomerase activation activity and can be extracted from various species in the genus Astragalus.

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400-920-2911

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生物活性

实验方案

技术信息

生物活性

描述Cycloastragenol (CAG) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus (Fisch.) Bunge. CAG activates telomerase in humans and ameliorates various biomarkers. CAG is absorbed through the intestinal epithelium via passive diffusion and undergoes first-pass hepatic metabolism. Within a certain dose range, oral CAG is relatively safe^[1]. CAG (5, 10, 20 mg/kg) dose-dependently reduced brain infarct volume, significantly ameliorated functional deficits, and prevented neuronal cell loss in MCAO (middle cerebral artery occlusion) mice. Meanwhile, CAG significantly reduced matrix metalloproteinase-9 activity, prevented tight junction degradation and subsequently ameliorated blood-brain barrier disruption. Moreover, CAG significantly upregulated SIRT1 expression in the ischemic brain but did not directly activate its enzymatic activity^[2]. CAG alleviates age-related bone loss and improves bone microstructure and biomechanical properties^[3]. CAG improved the chondrogenic differentiation of hAMSCs（human adipose-derived mesenchymal stem cells）, maintaining stable the active chondrocyte phenotype in up to 28 days of 3D in vitro chondrogenic culture^[4].
参考文献

[1] Yu Y, Zhou L, Yang Y, Liu Y. Cycloastragenol: An exciting novel candidate for age-associated diseases. Exp Ther Med. 2018 Sep;16(3):2175-2182
[2] Li M, Li SC, Dou BK, Zou YX, Han HZ, Liu DX, Ke ZJ, Wang ZF. Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia. Acta Pharmacol Sin. 2020 Aug;41(8):1025-1032
[3] Yu Y, Wu J, Li J, Liu Y, Zheng X, Du M, Zhou L, Yang Y, Luo S, Hu W, Li L, Yao W, Liu Y. Cycloastragenol prevents age-related bone loss: Evidence in d-galactose-treated and aged rats. Biomed Pharmacother. 2020 Aug;128:110304
[4] Szychlinska MA, Calabrese G, Ravalli S, Parrinello NL, Forte S, Castrogiovanni P, Pricoco E, Imbesi R, Castorina S, Leonardi R, Di Rosa M, Musumeci G. Cycloastragenol as an Exogenous Enhancer of Chondrogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells. A Morphological Study. Cells. 2020 Feb 3;9(2):347

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0378 mL
- 10.1892 mL
- 20.3784 mL
- 5 mM
- 0.4076 mL
- 2.0378 mL
- 4.0757 mL
- 10 mM
- 0.2038 mL
- 1.0189 mL
- 2.0378 mL

技术信息

CAS号

78574-94-4

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C30H50O5

运输

蓝冰

分子量

490.72

别名

Astramembrangenin;Cyclosieversigenin;环黄芪醇

溶解度

DMSO	98.0 mg/mL (199.7 mM)
Water	Insoluble
Ethanol	18.0 mg/mL (36.7 mM)

动物实验配方

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